Sleep Promotes Downward Firing Rate Homeostasis
نویسندگان
چکیده
منابع مشابه
Cortical Firing and Sleep Homeostasis
The need to sleep grows with the duration of wakefulness and dissipates with time spent asleep, a process called sleep homeostasis. What are the consequences of staying awake on brain cells, and why is sleep needed? Surprisingly, we do not know whether the firing of cortical neurons is affected by how long an animal has been awake or asleep. Here, we found that after sustained wakefulness corti...
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Homeostatic mechanisms stabilize neural circuit function by keeping firing rates within a set-point range, but whether this process is gated by brain state is unknown. Here, we monitored firing rate homeostasis in individual visual cortical neurons in freely behaving rats as they cycled between sleep and wake states. When neuronal firing rates were perturbed by visual deprivation, they graduall...
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It has been postulated that homeostatic mechanisms maintain stable circuit function by keeping neuronal firing within a set point range, but such firing rate homeostasis has never been demonstrated in vivo. Here we use chronic multielectrode recordings to monitor firing rates in visual cortex of freely behaving rats during chronic monocular visual deprivation (MD). Firing rates in V1 were suppr...
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How can neural circuits maintain stable activity states when they are constantly being modified by Hebbian processes that are notorious for being unstable? A new synaptic plasticity mechanism is presented here that enables a neuron to obtain homeostasis of its firing rate over longer timescales while leaving the neuron free to exhibit fluctuating dynamics in response to external inputs. Mathema...
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We review a recent approach to the mean-field limits in neural networks that takes into account the stochastic nature of input current and the uncertainty in synaptic coupling. This approach was proved to be a rigorous limit of the network equations in a general setting, and we express here the results in a more customary and simpler framework. We propose a heuristic argument to derive these eq...
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ژورنال
عنوان ژورنال: Neuron
سال: 2021
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2020.11.001